Mutations in the Filaggrin are Predisposing Factor in Korean Children With Atopic Dermatitis
نویسندگان
چکیده
منابع مشابه
Mutations in the Filaggrin are Predisposing Factor in Korean Children With Atopic Dermatitis
PURPOSE Filaggrin (FLG) is a key protein that facilitates the terminal differentiation of the epidermis and the formation of the skin barrier. Recent studies showed that atopic dermatitis (AD) associates closely with loss-of-function mutations in the FLG gene. Asian and European populations differ in the frequencies of FLG mutations. Several FLG mutations, including 3321delA, E2422X, K4671X, S2...
متن کاملFilaggrin Mutation in Korean Patients with Atopic Dermatitis
PURPOSE Atopic dermatitis (AD) is a chronic, relapsing eczematous inflammatory skin disease. Mutations in the filaggrin gene (FLG) are major predisposing factors for AD. Ethnic differences exist between Asian and European populations in the frequency and spectrum of FLG mutations. Moreover, a distinct set of FLG mutations has been reported in Asian populations. The aim of this study was to exam...
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چکیده ندارد.
15 صفحه اولleptin and atopic dermatitis in korean elementary school children
the prevalence of atopic dermatitis (ad) and obesity have been increasing considerably in korean school-children. ad is a chronic pruritic recurrent inflammatory skin disorder. leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in ad has not yet been well understood. a total of 227 subjects out of 2,109 elementary school children were def...
متن کاملFilaggrin single nucleotide polymorphisms in atopic dermatitis.
Atopic dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin for which no monogenic cause has been identified so far. Meanwhile, the filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease. One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction wa...
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ژورنال
عنوان ژورنال: Allergy, Asthma & Immunology Research
سال: 2013
ISSN: 2092-7355,2092-7363
DOI: 10.4168/aair.2013.5.4.211